Orthosiphon stamineus: Traditional Uses, Phytochemistry, Pharmacology, and Toxicology

被引：71

作者：

Ameer, Omar Z. ^{[1
]}

Salman, Ibrahim M. ^{[1
]}

Asmawi, Mohammad Zaini ^{[1
]}

Ibraheem, Zaid O. ^{[1
]}

Yam, Mun Fei ^{[1
]}

机构：

[1] Univ Sains Malaysia, Sch Pharmaceut Sci, Dept Physiol & Pharmacol, Minden 11800, Penang, Malaysia

来源：

JOURNAL OF MEDICINAL FOOD | 2012年 / 15卷 / 08期

关键词：

folk medicine; Orthosiphon stamineus; pharmacological actions; phytochemical constituents; toxicological investigations; ISOPIMARANE-TYPE DITERPENES; BINDING-ACTIVITY; EXTRACT; FLAVONOIDS; LEAVES; ARISTATUS; BENTH; CONSTITUENTS; ANTIOXIDANT; INHIBITION;

D O I：

10.1089/jmf.2011.1973

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Orthosiphon stamineus Benth. (Lambiaceae) is an important plant in traditional folk medicine. This review is a comprehensive summary of the currently available chemical, pharmacological, and toxicological investigations as well as the traditional and therapeutic uses of this plant. Different in vitro and in vivo models have been addressed along with a survey of all phytochemicals identified in this plant, including flavonoids, terpenoids, and essential oils. Previous studies revealed that O. stamineus possesses several pharmacological activities, which are attributed to its phytochemical content. It was found that O. stamineus exhibits diuretic, hypouricemic, renal protective, antioxidant, anti-inflammatory, hepatoprotective, gastroprotective, antihypertensive, antidiabetic, antihyperlipidemic, antimicrobial, and anorexic activities. In conclusion, O. stamineus has wide traditional and pharmacological uses in various pathophysiological conditions. Therefore, it is an attractive subject for further experimental and clinical investigations.

引用

页码：678 / 690

页数：13

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