MicroRNA Signatures: Novel Biomarker for Colorectal Cancer?

被引：201

作者：

Luo, Xiaoya ^{[1
]}

Burwinkel, Barbara ^{[2
,3
]}

Tao, Sha ^{[1
]}

Brenner, Hermann ^{[1
]}

机构：

[1] German Canc Res Ctr, Div Clin Epidemiol & Aging Res, D-69120 Heidelberg, Germany

[2] German Canc Res Ctr, Mol Epidemiol Grp, D-69120 Heidelberg, Germany

[3] Univ Heidelberg, Div Mol Biol Breast Canc, Dept Gynecol & Obstet, Heidelberg, Germany

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2011年 / 20卷 / 07期

关键词：

COLON-CANCER; CIRCULATING MICRORNAS; EXPRESSION PROFILES; BREAST-CANCER; ADENOCARCINOMA; MIR-143; PLASMA; SERUM; MIR-21; GENES;

D O I：

10.1158/1055-9965.EPI-11-0035

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aberrant microRNA (miRNA) expression might be of potential use as diagnostic and prognostic biomarker for cancers. We reviewed studies published until March 2011 which assessed expression of miRNAs in colorectal cancer (CRC)/adenoma tissue and normal colorectal mucosa and in plasma of CRC/adenoma patients and healthy controls. Overall, 20 studies that investigated miRNA expression in tissue and 3 studies that investigated miRNA levels in plasma were included. A total of 160 miRNAs were found to be dysregulated in CRC. MiR-20a and miR-31 were found to be significantly upregulated in more than one study, and miR-143 and miR-145 were found to be significantly downregulated in CRC tissue in six or more studies. MiR-92a was significantly upregulated in CRC patients in two of the plasma-based studies and in CRC tissue in one of the tissue-based studies. Our results provide timely and relevant information for miRNAs as potential diagnostic biomarkers for CRC. The expression of miRNAs in plasma may be indicative of presence of CRC. Larger diagnostic studies are needed to evaluate potential use of miRNA expression in early detection and diagnosis of CRC. Cancer Epidemiol Biomarkers Prev; 20(7); 1272-86. (C)2011 AACR.

引用

页码：1272 / 1286

页数：15

共 46 条

[1] miRNAs in colon and rectal cancer: A consensus for their true clinical value [J].

Agostini, Marco ;

Pucciarelli, Salvatore ;

Calore, Federica ;

Bedin, Chiara ;

Enzo, MariaVittoria ;

Nitti, Donato .

CLINICA CHIMICA ACTA, 2010, 411 (17-18) :1181-1186

[2]

[Anonymous], NUCL ACIDS RES

[3] Characterization of global microRNA expression reveals oncogenic potential of miR-145 in metastatic colorectal cancer [J].

Arndt, Greg M. ;

Dossey, Lesley ;

Cullen, Lara M. ;

Lai, Angela ;

Druker, Riki ;

Eisbacher, Michael ;

Zhang, Chunyan ;

Tran, Nham ;

Fan, Hongtao ;

Retzlaff, Kathy ;

Bittner, Anton ;

Raponi, Mitch .

BMC CANCER, 2009, 9 :374

[4] Epigenetic Silencing of miR-137 Is an Early Event in Colorectal Carcinogenesis [J].

Balaguer, Francesc ;

Link, Alexander ;

Lozano, Juan Jose ;

Cuatrecasas, Miriam ;

Nagasaka, Takeshi ;

Boland, C. Richard ;

Goel, Ajay .

CANCER RESEARCH, 2010, 70 (16) :6609-6618

[5] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[6] MicroRNA signatures in human cancers [J].

Calin, George A. ;

Croce, Carlo M. .

NATURE REVIEWS CANCER, 2006, 6 (11) :857-866

[7] MicroRNA expression profiling to identify and validate reference genes for relative quantification in colorectal cancer [J].

Chang, Kah Hoong ;

Mestdagh, Pieter ;

Vandesompele, Jo ;

Kerin, Michael J. ;

Miller, Nicola .

BMC CANCER, 2010, 10

[8] Role of miR-143 targeting KRAS in colorectal tumorigenesis [J].

Chen, X. ;

Guo, X. ;

Zhang, H. ;

Xiang, Y. ;

Chen, J. ;

Yin, Y. ;

Cai, X. ;

Wang, K. ;

Wang, G. ;

Ba, Y. ;

Zhu, L. ;

Wang, J. ;

Yang, R. ;

Zhang, Y. ;

Ren, Z. ;

Zen, K. ;

Zhang, J. ;

Zhang, C-Y .

ONCOGENE, 2009, 28 (10) :1385-1392

[9] Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases [J].

Chen, Xi ;

Ba, Yi ;

Ma, Lijia ;

Cai, Xing ;

Yin, Yuan ;

Wang, Kehui ;

Guo, Jigang ;

Zhang, Yujing ;

Chen, Jiangning ;

Guo, Xing ;

Li, Qibin ;

Li, Xiaoying ;

Wang, Wenjing ;

Zhang, Yan ;

Wang, Jin ;

Jiang, Xueyuan ;

Xiang, Yang ;

Xu, Chen ;

Zheng, Pingping ;

Zhang, Juanbin ;

Li, Ruiqiang ;

Zhang, Hongjie ;

Shang, Xiaobin ;

Gong, Ting ;

Ning, Guang ;

Wang, Jun ;

Zen, Ke ;

Zhang, Junfeng ;

Zhang, Chen-Yu .

CELL RESEARCH, 2008, 18 (10) :997-1006

[10] Aberrant Expression of miR-203 and Its Clinical Significance in Gastric and Colorectal Cancers [J].

Chiang, Yeunpo ;

Song, Yongxi ;

Wang, Zhenning ;

Chen, Yue ;

Yue, Zhenyu ;

Xu, Huimian ;

Xing, Chengzhong ;

Liu, Zhuangkai .

JOURNAL OF GASTROINTESTINAL SURGERY, 2011, 15 (01) :63-70

← 1 2 3 4 5 →