Mammalian tight junctions in the regulation of epithelial differentiation and proliferation

被引：257

作者：

Matter, K ^{[1
]}

Aijaz, S ^{[1
]}

Tsapara, A ^{[1
]}

Balda, MS ^{[1
]}

机构：

[1] UCL, Inst Ophthalmol, Div Cell Biol, London EC1V 9EL, England

来源：

CURRENT OPINION IN CELL BIOLOGY | 2005年 / 17卷 / 05期

基金：

英国医学研究理事会; 英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/j.ceb.2005.08.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tight junctions are important for the permeability properties of epithelial and endothelial barriers as they restrict diffusion along the paracellular space. Recent observations have revealed that tight junctions also function in the regulation of epithelial proliferation and differentiation. They harbour evolutionarily conserved protein complexes that regulate polarisation and junction assembly. Tight junctions also recruit signalling proteins that participate in the regulation of cell proliferation and differentiation. These signalling proteins include components that affect established signalling cascades and dual localisation proteins that can associate with junctions as well as travel to the nucleus where they regulate gene expression.

引用

页码：453 / 458

页数：6

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