Differential responses of human liver cancer and normal cells to atmospheric pressure plasma

被引：55

作者：

Gweon, Bomi ^{[2
]}

Kim, Mina ^{[1
]}

Kim, Dan Bee ^{[2
]}

Kim, Daeyeon ^{[1
]}

Kim, Hyeonyu ^{[1
]}

Jung, Heesoo ^{[2
]}

Shin, Jennifer H. ^{[1
,3
]}

Choe, Wonho ^{[2
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Mech Engn, Taejon 305701, South Korea

[2] Korea Adv Inst Sci & Technol, Dept Phys, Taejon 305701, South Korea

[3] Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Taejon 305701, South Korea

来源：

APPLIED PHYSICS LETTERS | 2011年 / 99卷 / 06期

关键词：

BARRIER DISCHARGE PLASMA;

D O I：

10.1063/1.3622631

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

When treated by atmospheric pressure plasma, human liver cancer cells (SK-HEP-1) and normal cells (THLE-2) exhibited distinctive cellular responses, especially in relation to their adhesion behavior. We discovered the critical threshold voltage of 950 V, biased at the electrode of the micro-plasma jet source, above which SK-HEP-1 started to detach from the substrate while THLE-2 remained intact. Our mechanical and biochemical analyses confirmed the presence of intrinsic differences in the adhesion properties between the cancer and the normal liver cells, which provide a clue to the differential detachment characteristics of cancer and normal cells to the atmospheric pressure plasma. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3622631]

引用

页数：3

共 15 条

[1] Protein destruction by a helium atmospheric pressure glow discharge: Capability and mechanisms [J].

Deng, X. T. ;

Shi, J. J. ;

Kong, M. G. .

JOURNAL OF APPLIED PHYSICS, 2007, 101 (07)

[2] Applied plasma medicine [J].

Fridman, Gregory ;

Friedman, Gary ;

Gutsol, Alexander ;

Shekhter, Anatoly B. ;

Vasilets, Victor N. ;

Fridman, Alexander .

PLASMA PROCESSES AND POLYMERS, 2008, 5 (06) :503-533

[3] Floating electrode dielectric barrier discharge plasma in air promoting apoptotic behavior in melanoma skin cancer cell lines [J].

Fridman, Gregory ;

Shereshevsky, Alexey ;

Jost, Monika M. ;

Brooks, Ari D. ;

Fridman, Alexander ;

Gutsol, Alexander ;

Vasilets, Victor ;

Friedman, Gary .

PLASMA CHEMISTRY AND PLASMA PROCESSING, 2007, 27 (02) :163-176

[4] Focal adhesion size controls tension-dependent recruitment of α-smooth muscle actin to stress fibers [J].

Goffin, JM ;

Pittet, P ;

Csucs, G ;

Lussi, JW ;

Meister, JJ ;

Hinz, B .

JOURNAL OF CELL BIOLOGY, 2006, 172 (02) :259-268

[5] Plasma effects on subcellular structures [J].

Gweon, Bomi ;

Kim, Daeyeon ;

Kim, Dan Bee ;

Jung, Heesoo ;

Choe, Wonho ;

Shin, Jennifer H. .

APPLIED PHYSICS LETTERS, 2010, 96 (10)

[6] Escherichia coli deactivation study controlling the atmospheric pressure plasma discharge conditions [J].

Gweon, Bomi ;

Kim, D. B. ;

Moon, S. Y. ;

Choe, W. .

CURRENT APPLIED PHYSICS, 2009, 9 (03) :625-628

[7] Mechanism of blood coagulation by nonthermal atmospheric pressure dielectric barrier discharge plasma [J].

Kalghatgi, Sameer U. ;

Fridman, Gregory ;

Cooper, Moogega ;

Nagaraj, Gayathri ;

Peddinghaus, Marie ;

Balasubramanian, Manjula ;

Vasilets, Victor N. ;

Gutsol, Alexander F. ;

Fridman, Alexander ;

Friedman, Gary .

IEEE TRANSACTIONS ON PLASMA SCIENCE, 2007, 35 (05) :1559-1566

[8] Reattachment and apoptosis after plasma-needle treatment of cultured cells [J].

Kieft, Ingrid E. ;

Kurdi, Moamina ;

Stoffels, Eva .

IEEE TRANSACTIONS ON PLASMA SCIENCE, 2006, 34 (04) :1331-1336

[9] Comparative study of atmospheric pressure low and radio frequency microjet plasmas produced in a single electrode configuration [J].

Kim, Dan Bee ;

Rhee, J. K. ;

Gweon, B. ;

Moon, S. Y. ;

Choe, W. .

APPLIED PHYSICS LETTERS, 2007, 91 (15)

[10] Air plasma coupled with antibody-conjugated nanoparticles: a new weapon against cancer [J].

Kim, G. C. ;

Kim, G. J. ;

Park, S. R. ;

Jeon, S. M. ;

Seo, H. J. ;

Iza, F. ;

Lee, J. K. .

JOURNAL OF PHYSICS D-APPLIED PHYSICS, 2009, 42 (03)

← 1 2 →