Me2Zn-mediated addition of acetylenes to aldehydes and ketones

被引：52

作者：

Cozzi, PG

Rudolph, J

Bolm, C

Norrby, PO

Tomasini, C

机构：

[1] Univ Bologna, Dipartimento Chim G Ciamician, Alma Mater Studiorum, I-40126 Bologna, Italy

[2] Univ Aachen, Rhein Westfal TH Aachen, Inst Organ Chem, D-52056 Aachen, Germany

[3] Tech Univ Denmark, Dept Chem, DK-2800 Lyngby, Denmark

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 14期

关键词：

D O I：

10.1021/jo050115r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Contrary to expectations, commercially available 2 M Me2Zn in toluene is able to promote the addition of phenylacetylene to aldehydes and ketones. This reactivity is determined by a new, unprecedented mechanism, which involves activation of the zinc reagent via coordination with carbonyl substrates that behave "ligand like". Broad scope, high tolerance to functional groups, and a simple procedure make this new method highly interesting for the synthetic chemist.

引用

页码：5733 / 5736

页数：4

共 44 条

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