MicroRNAs

被引：174

作者：

Fabbri, Muller ^{[2
]}

Croce, Carlo M. ^{[2
]}

Calin, George A. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Canc Genet, Dept Expt Therapeut, Houston, TX 77030 USA

[2] Ohio State Univ, Columbus, OH 43210 USA

来源：

CANCER JOURNAL | 2008年 / 14卷 / 01期

关键词：

microRNAs; ultraconserved regions; B cells; oncogene; tumor suppressor gene;

D O I：

10.1097/PPO.0b013e318164145e

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs (miRNAs) are small, noncoding RNAs with regulatory functions, which play an important role in many human diseases, including cancer. An emerging number of studies show that miRNAs can act either as oncogenes or as tumor suppressor genes or sometimes as both. Germline, somatic mutations and polymorphisms can contribute to cancer predisposition. miRNA expression levels have diagnostic and prognostic implications, and their roles as anticancer therapeutic agents is promising and currently under investigation.

引用

页码：1 / 6

页数：6

共 82 条

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