Role of oxidative carbonylation in protein quality control and senescence

被引：587

作者：

Nyström, T ^{[1
]}

机构：

[1] Gothenburg Univ, Dept Cell & Mol Biol Microbiol, S-41390 Gothenburg, Sweden

来源：

EMBO JOURNAL | 2005年 / 24卷 / 07期

关键词：

damage segregation; mistranslation; protein carbonylation; proteolysis; senescence;

D O I：

10.1038/sj.emboj.7600599

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Proteins can become modified by a large number of reactions involving reactive oxygen species. Among these reactions, carbonylation has attracted a great deal of attention due to its irreversible and unrepairable nature. Carbonylated proteins are marked for proteolysis by the proteasome and the Lon protease but can escape degradation and form high-molecular-weight aggregates that accumulate with age. Such carbonylated aggregates can become cytotoxic and have been associated with a large number of age-related disorders, including Parkinson's disease, Alzheimer's disease, and cancer. This review focuses on the generation of and defence against protein carbonyls and speculates on the potential role of carbonylation in protein quality control, cellular deterioration, and senescence.

引用

页码：1311 / 1317

页数：7

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