High performance liquid chromatography enantioseparation of chiral pharmaceuticals using tris(chloro-methylphenylcarbamate)s of cellulose

Chiral recognition abilities of a recently developed new type of cellulose phenylcarbamates were studied. These chiral stationary phases (CSPs) simultaneously contain both electron-withdrawing (Cl) and electron-donating (CH3) substituents on the phenyl moiety. Chiral pharmaceuticals which belong to the various pharmacological groups (sedatives, hypnotics, anticonvulsants, Ca2+ channel blockers, beta-blockers, antitusives, antihystaminics, choleretics, diuretics, antimycotics, etc) were resolved to enantiomers. These new CSPs sometimes exhibit alternative chiral recognition ability to that most successful commercially available cellulosic CSP Chiralcel-OD and can be used as a good complement to it in analytical and preparative scale enantioseparations.