Copper(I)-mediated preparation of new pyrano[3′,4′:4,5]imidazo[1,2-a]pyridin-1-one compounds under mild palladium-free conditions

被引:15
作者
Bahlaouan, Zineb [1 ]
Abarbri, Mohamed [1 ]
Duchene, Alain [1 ]
Thibonnet, Jerome [1 ]
Henry, Nicolas [2 ]
Enguehard-Gueiffier, Cecile [2 ]
Gueiffier, Alain [2 ]
机构
[1] Univ Tours, Fac Sci, Lab PhysicoChim Mat Biomol EA 4244, F-37200 Tours, France
[2] Univ Tours, Fac Pharm, Lab PhysicoChim Mat Biomol EA 4244, F-37200 Tours, France
关键词
CATALYZED COUPLING REACTION; ARYL HALIDES; TERMINAL ACETYLENES; HIGHLY EFFICIENT; C-N; STEREOSELECTIVE-SYNTHESIS; SELECTIVE SYNTHESIS; ETHER FORMATION; ALPHA-PYRONES; CYCLIZATION;
D O I
10.1039/c0ob00622j
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A general and efficient Cu(I)-mediated cross-coupling and heterocyclization reaction of 3-iodoimidazo[1,2-a]pyridine-2-carboxylic acid, and terminal alkynes was developed under very mild conditions. This method allows the introduction in one pot of a third ring fused in positions 2 and 3 of the imidazo[1,2-a]pyridine core with reasonable yields and total regioselectivity. This procedure does not require the use of any expensive supplementary additives, and is palladium-free.
引用
收藏
页码:1212 / 1218
页数:7
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