In vitro analysis of cisplatin functionalized magnetic nanoparticles in combined cancer chemotherapy and electromagnetic hyperthermia

被引：89

作者：

Babincova, Melania ^{[1
]}

Altanerova, Veronika ^{[2
]}

Altaner, Cestmir ^{[2
]}

Bergemann, Christian ^{[3
]}

Babinec, Peter ^{[1
]}

机构：

[1] Comenius Univ, Dept Nucl Phys & Biophys, Bratislava 84248, Slovakia

[2] Slovak Acad Sci, Canc Res Inst, Bratislava 83391, Slovakia

[3] Chemicell GmbH, D-12103 Berlin, Germany

来源：

IEEE TRANSACTIONS ON NANOBIOSCIENCE | 2008年 / 7卷 / 01期

关键词：

cis-diamminedichloroplatinum(II) (cisplatin); combined hyperthermia; electromagnetic field; magnetic nanoparticles; minimally invasive therapy; targeted tumor cell killing;

D O I：

10.1109/TNB.2008.2000145

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel platform has been developed for combined cancer chemotherapy and hyperthermia based on iron oxide magnetic nanoparticles functionalized with cis-diamminedichloroplatinum(II) (cisplatin). The capabilities of this system for heating and controlled drug release were investigated, and the system was tested in vitro by the treatment of BP6 rat sarcoma cells, where we demonstrated a synergism between the effects of cisplatin-targetMAG nanoparticles and the application of electromagnetic field.

引用

页码：15 / 19

页数：5

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[1] Dopamine mediated iron release from ferritin is enhanced at higher temperatures:: Possible implications for fever induced Parkinson's disease [J].