A template-based mnemonic for monoamine oxidase (MAO-N) catalyzed reactions and its application to the chemo-enzymatic deracemisation of the alkaloid (±)-crispine A

被引：72

作者：

Bailey, Kevin R. ^{[1
]}

Ellis, Andrew J. ^{[1
]}

Reiss, Renate ^{[1
]}

Snape, Timothy J. ^{[1
]}

Turner, Nicholas J. ^{[1
]}

机构：

[1] Univ Manchester, Sch Chem, Manchester Interdisciplinary Bioctr, Manchester M1 7DN, Lancs, England

来源：

CHEMICAL COMMUNICATIONS | 2007年 / 35期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1039/b710456a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A template-based mnemonic has been developed for the enzyme monoamine oxidase from Aspergillus niger and has been used to successfully identify the alkaloid (+/-)-crispine A as a target for chemo-enzymatic deracemisation yielding the biologically active (R)-enantiomer in 97% e.e.

引用

页码：3640 / 3642

页数：3

共 18 条

[1]

Alexeeva M, 2002, ANGEW CHEM INT EDIT, V41, P3177, DOI 10.1002/1521-3773(20020902)41:17<3177::AID-ANIE3177>3.0.CO

[2]

2-P

[3] SYNTHESES OF 7,8-BENZOPYRROCOLINE DERIVATIVES - A NOVEL REACTION OF REISSERT COMPOUNDS [J].