Genome wide analysis of retroviral DNA integration

被引：309

作者：

Bushman, F ^{[1
]}

Lewinski, M ^{[1
]}

Ciuffi, A ^{[1
]}

Barr, S ^{[1
]}

Leipzig, J ^{[1
]}

Hannenhalli, S ^{[1
]}

Hoffmann, C ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Dept Microbiol, Philadelphia, PA 19104 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2005年 / 3卷 / 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrmicro1263

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Retroviral vectors are often used to introduce therapeutic sequences into patients' cells. In recent years, gene therapy with retroviral vectors has had impressive therapeutic successes, but has also resulted in three cases of leukaemia caused by insertional mutagenesis, which has focused attention on the molecular determinants of retroviral-integration target-site selection. Here, we review retroviral DNA integration, with emphasis on recent genome-wide studies of targeting and on the status of efforts to modulate target-site selection.

引用

页码：848 / 858

页数：11

共 92 条

[81] Human cell proteins and human immunodeficiency virus DNA integration
Turlure, F
Devroe, E
Silver, PA
Engelman, A
[J]. FRONTIERS IN BIOSCIENCE-LANDMARK, 2004, 9 : 3187 - 3208
[82] Cellular gene expression upon human immunodeficiency virus type 1 infection of CD4+-T-cell lines
van't Wout, AB
Lehrman, GK
Mikheeva, SA
O'Keefe, GC
Katze, MG
Bumgarner, RE
Geiss, GK
Mullins, JI
[J]. JOURNAL OF VIROLOGY, 2003, 77 (02) : 1392 - 1402
[83] The sequence of the human genome
Venter, JC
Adams, MD
Myers, EW
Li, PW
Mural, RJ
Sutton, GG
Smith, HO
Yandell, M
Evans, CA
Holt, RA
Gocayne, JD
Amanatides, P
Ballew, RM
Huson, DH
Wortman, JR
Zhang, Q
Kodira, CD
Zheng, XQH
Chen, L
Skupski, M
Subramanian, G
Thomas, PD
Zhang, JH
Miklos, GLG
Nelson, C
Broder, S
Clark, AG
Nadeau, C
McKusick, VA
Zinder, N
Levine, AJ
Roberts, RJ
Simon, M
Slayman, C
Hunkapiller, M
Bolanos, R
Delcher, A
Dew, I
Fasulo, D
Flanigan, M
Florea, L
Halpern, A
Hannenhalli, S
Kravitz, S
Levy, S
Mobarry, C
Reinert, K
Remington, K
Abu-Threideh, J
Beasley, E
[J]. SCIENCE, 2001, 291 (5507) : 1304 - +
[84] The human transcriptome map reveals extremes in gene density, intron length, GC content, and repeat pattern for domains of highly and weakly expressed genes
Versteeg, R
van Schaik, BDC
van Batenburg, MF
Roos, M
Monajemi, R
Caron, H
Bussemaker, HJ
van Kampen, AHC
[J]. GENOME RESEARCH, 2003, 13 (09) : 1998 - 2004
[85] ACCEPTOR SITES FOR RETROVIRAL INTEGRATIONS MAP NEAR DNASE I-HYPERSENSITIVE SITES IN CHROMATIN
VIJAYA, S
STEFFEN, DL
ROBINSON, HL
[J]. JOURNAL OF VIROLOGY, 1986, 60 (02) : 683 - 692
[86] VIRAL DYNAMICS IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION
WEI, XP
GHOSH, SK
TAYLOR, ME
JOHNSON, VA
EMINI, EA
DEUTSCH, P
LIFSON, JD
BONHOEFFER, S
NOWAK, MA
HAHN, BH
SAAG, MS
SHAW, GM
[J]. NATURE, 1995, 373 (6510) : 117 - 122
[87] Relationship between retroviral DNA integration and gene expression
Weidhaas, JB
Angelichio, EL
Fenner, S
Coffin, JM
[J]. JOURNAL OF VIROLOGY, 2000, 74 (18) : 8382 - 8389
[88] DISTRIBUTION OF TARGETS FOR AVIAN RETROVIRUS DNA INTEGRATION IN-VIVO
WITHERSWARD, ES
KITAMURA, Y
BARNES, JP
COFFIN, JM
[J]. GENES & DEVELOPMENT, 1994, 8 (12) : 1473 - 1487
[89] Recovery of replication-competent HIV despite prolonged suppression of plasma viremia
Wong, JK
Hezareh, M
Gunthard, HF
Havlir, DV
Ignacio, CC
Spina, CA
Richman, DD
[J]. SCIENCE, 1997, 278 (5341) : 1291 - 1295
[90] Transcription start regions in the human genome are favored targets for MLV integration
Wu, XL
Li, Y
Crise, B
Burgess, SM
[J]. SCIENCE, 2003, 300 (5626) : 1749 - 1751

← 1 2 3 4 5 6 7 8 9 10 →