Copper-Catalyzed Trifluoromethylation of Unactivated Olefins

被引：366

作者：

Parsons, Andrew T. ^{[1
]}

Buchwald, Stephen L. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 39期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

copper; fluorine; homogeneous catalysis; radicals; trifluoromethylation; MILD ELECTROPHILIC TRIFLUOROMETHYLATION; NUCLEOPHILIC TRIFLUOROMETHYLATION; RUTHENIUM(II) COMPLEX; REDUCTIVE ELIMINATION; DIARYLIODONIUM SALTS; CARBONYL-COMPOUNDS; STABLE REAGENTS; BORONIC ACIDS; PERFLUOROALKYLATION; REACTIVITY;

D O I：

10.1002/anie.201104053

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Activating the inactive: A copper-catalyzed allylic trifluoromethylation of unactivated terminal olefins proceeds under mild conditions to produce linear allylic trifluoromethylated products with high E/Z selectivity (see scheme). The reaction can be applied to a range of substrates bearing numerous functional groups. Furthermore, the reaction is scalable and amenable to a benchtop setup. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9120 / 9123

页数：4

共 57 条

[1] Enantioselective α-Arylation of Aldehydes via the Productive Merger of lodonium Salts and Organocatalysis [J].