Geometric formalism for DNA quadruplex folding

被引：196

作者：

da Silva, Mateus Webba ^{[1
]}

机构：

[1] Univ Ulster, Sch Biomed Sci, CMB, Coleraine BT52 1SA, Londonderry, North Ireland

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2007年 / 13卷 / 35期

关键词：

DNA structures; glycosides; guanine;

D O I：

10.1002/chem.200701255

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Understanding the control of self-assembly and stereochemical properties of DNA higher order architectural folds is of fundamental importance in biology as well as biochemical technological applications. Guanine-rich DNA sequences can form tetrahelical architectures termed quadruplexes. A formalism is presented describing the interdependency of a set of structural descriptors as a geometric basis for folding of unimolecular quadruplex topologies. It represents a standard for interpretation of structural characteristics of quadruplexes, and is comprehensive in explicitly harmonizing the results of published literature with a unified language. The formalism is a fundamental step towards prediction of unimolecular quadruplex folding topologies from primary sequence.

引用

页码：9738 / 9745

页数：8

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