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The influence of infections on the development and severity of allergic disorders

被引：66
作者：
Herz, U
Lacy, P
Renz, H
Erb, K
机构：
[1] Univ Wurzburg, Ctr Infect Dis, D-97070 Wurzburg, Germany
[2] Univ Marburg Hosp, Cent Lab, Dept Clin Chem & Mol Diagnost, D-35033 Marburg, Germany
[3] Univ Alberta, Dept Med, Edmonton, AB T6G 2S2, Canada
来源：
CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 06期
关键词：
D O I：
10.1016/S0952-7915(00)00155-2
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The frequency and severity of atopic disorders are steadily increasing, particularly in developing countries. The reason for this observation is not clear. Recent studies indicate that infections with viruses and especially with bacteria early in life may help to inhibit allergic Th2 responses by skewing the immune system towards Th1 responses. However, infections can also lead to the exacerbation of atopic disorders.
引用
收藏
页码：632 / 640
页数：9
相关论文
共 66 条
[21]   Relation between house-dust endotoxin exposure, type 1 T cell development, and allergen sensitisation in infants at high risk of asthma [J].
Gereda, JE ;
Leung, DYM ;
Thatayatikom, A ;
Streib, JE ;
Price, MR ;
Klinnert, MD ;
Liu, AH .
LANCET, 2000, 355 (9216) :1680-1683
[22]   Rhinovirus-mediated changes in airway smooth muscle responsiveness:: induced autocrine role of interleukin-1β [J].
Hakonarson, H ;
Carter, C ;
Maskeri, N ;
Hodinka, R ;
Grunstein, MM .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 1999, 277 (01) :L13-L21
[23]  
Hall LR, 1998, INFECT IMMUN, V66, P4425
[24]  
Handzel ZT, 1998, J IMMUNOL, V160, P1279
[25]   Respiratory syncytical virus-induced chemokine expression in the lower airways - Eosinophil recruitment and degranulation [J].
Harrison, AM ;
Bonville, CA ;
Rosenberg, HF ;
Domachowske, JB .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1999, 159 (06) :1918-1924
[26]   BCG infection suppresses allergic sensitization and development of increased airway reactivity in an animal model [J].
Herz, U ;
Gerhold, K ;
Grüber, C ;
Braun, A ;
Wahn, U ;
Renz, H ;
Paul, K .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1998, 102 (05) :867-874
[27]   Chemokines in allergy [J].
Homey, B ;
Zlotnik, A .
CURRENT OPINION IN IMMUNOLOGY, 1999, 11 (06) :626-634
[28]  
Imani F, 1999, J IMMUNOL, V162, P1597
[29]  
Jacoby DB, 1999, CLIN EXP ALLERGY, V29, P59
[30]  
Johnston SL, 1998, J IMMUNOL, V160, P6172
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