Three new furan derivatives and a new fatty acid from a Taiwanese marine sponge Plakortis simplex

被引：42

作者：

Shen, YC

Prakash, CVS

Kuo, YH

机构：

[1] Natl Sun Yat Sen Univ, Inst Marine Resources, Kaohsiung 80424, Taiwan

[2] Natl Res Inst Chinese Med, Taipei, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 03期

关键词：

D O I：

10.1021/np000413d

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new furan derivatives, plakorsins A-C (6-8), together with a new fatty acid, plakortic acid (9), have been isolated from the Taiwanese marine sponge Plakortis simplex in addition to the known metabolites chondrillin (1), 6-epi-chondrillin (2), 2-oxo-2,5-dihydrofuran-5-acetic acid methyl ester (methyl 1,4-epoxy-1-oxo-2-hexenoate) (3), dimethyl beta -ketoadipate (4), and the monomethyl ester of cis,cis-muconic acid (5). The structures of these compounds were established mainly on the basis of spectral data and chemical methods. Biological studies revealed that compound 7 exhibited cytotoxic activity against COLO-250 and KB-16 cells, and compound 1 is active against KB-16 cells.

引用

页码：324 / 327

页数：4

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