Polymeric supports for solid phase synthesis

被引:36
作者
Labadie, JW [1 ]
机构
[1] Argonaut Technol, San Carlos, CA 94070 USA
关键词
D O I
10.1016/S1367-5931(98)80008-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The nature of the polymer support plays an integral role in solid phase organic synthesis. Combinatorial and highly parallel synthetic strategies have stimulated the development of new polymer support materials with compositions and properties that allow a broader spectrum of organic transformations. Extension of solid phase organic synthesis to encoded microreactors provides an efficient methodology for preparing large numbers of discrete compounds.
引用
收藏
页码:346 / 352
页数:7
相关论文
共 54 条
[41]   A new route to (chloromethyl)styrene polymers [J].
Sheng, Q ;
Stover, HDH .
MACROMOLECULES, 1997, 30 (21) :6712-6714
[42]   Selective functionalization of poly(4-methylstyrene) [J].
Sheng, Q ;
Stover, HDH .
MACROMOLECULES, 1997, 30 (21) :6451-6457
[43]  
SHERRINGTON DC, 1981, POLYM SUPPORTED REAC, P1
[44]  
Shi SH, 1998, BIOTECHNOL BIOENG, V61, P7, DOI 10.1002/(SICI)1097-0290(199824)61:1<7::AID-BIT4>3.0.CO
[45]  
2-N
[46]   Polymer-supported synthesis as a tool for improving chemoselectivity: Pauson-Khand reaction [J].
Spitzer, JL ;
Kurth, MJ ;
Schore, NE .
TETRAHEDRON, 1997, 53 (20) :6791-6808
[47]   Functional polymers from (vinyl)polystyrene. Short routes to binding functional groups to polystyrene resin through a dimethylene spacer: Bromine, sulfur, phosphorus, silicon, hydrogen, boron, and oxygen [J].
Stranix, BR ;
Gao, JP ;
Barghi, R ;
Salha, J ;
Darling, GD .
JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (26) :8987-8993
[48]   Solid-phase dendrimer synthesis and the generation of super-high-loading resin beads for combinatorial chemistry [J].
Swali, V ;
Wells, NJ ;
Langley, GJ ;
Bradley, M .
JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (15) :4902-4903
[49]   Secondary amide-based linkers for solid phase organic synthesis [J].
Swayze, EE .
TETRAHEDRON LETTERS, 1997, 38 (49) :8465-8468
[50]   A simple procedure for the solid phase synthesis of diketopiperazine and diketomorpholine derivatives [J].
Szardenings, AK ;
Burkoth, TS ;
Lu, HH ;
Tien, DW ;
Campbell, DA .
TETRAHEDRON, 1997, 53 (19) :6573-6593