MEDICAL PROGRESS Acute HIV-1 Infection

被引：462

作者：

Cohen, Myron S. ^{[1
]}

Shaw, George M. ^{[3
]}

McMichael, Andrew J. ^{[4
,5
]}

Haynes, Barton F. ^{[2
]}

机构：

[1] Univ N Carolina, Inst Global Hlth & Infect Dis, Chapel Hill, NC USA

[2] Duke Univ, Sch Med, Duke Human Vaccine Inst, Durham, NC USA

[3] Univ Alabama Birmingham, Birmingham, AL USA

[4] Univ Oxford, Weatherall Inst Mol Med, Oxford, England

[5] Univ Oxford, Natl Inst Hlth Res, Biomed Res Ctr, Oxford, England

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2011年 / 364卷 / 20期

基金：

美国国家卫生研究院;

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; CD4(+) T-CELLS; ANTIRETROVIRAL THERAPY; SEXUAL TRANSMISSION; INTEGRIN ALPHA(4)BETA(7); PARTNER NOTIFICATION; RESPONSES; STAGE; SIV; VIREMIA;

D O I：

10.1056/NEJMra1011874

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

IN 2009, THE UNITED NATIONS ESTIMATED THAT 33.2 MILLION PEOPLE worldwide were living with human immunodeficiency virus type 1 (HIV-1) infection and that 2.6 million people had been newly infected.(1) The need for effective HIV-1 prevention has never been greater. In this review, we address recent critical advances in our understanding of HIV-1 transmission and acute HIV-1 infection. Fourth-generation HIV-1 testing, now available worldwide,(2,3) will allow the diagnosis of infection in many patients and may lead to new treatments and opportunities for prevention.

引用

页码：1943 / 1954

页数：12

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