Accommodation of a single protein guest in nanometer-scale wells embedded in a "DNA Nanotape"

被引：27

作者：

Kuzuya, Akinori ^{[1
]}

Numajiri, Kentaro ^{[1
]}

Komiyama, Makoto ^{[1
]}

机构：

[1] Univ Tokyo, Adv Sci & Technol Res Ctr, Tokyo 1538904, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 18期

关键词：

DNA; host-guest systems; nanostructures; protein arrays; scanning probe microscopy;

D O I：

10.1002/anie.200800028

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

All's well: A tapelike DNA scaffold with regularly arranged nanometer-scale wells is prepared by bundling nine DNA helices into U-shaped motifs (see picture). By attaching two biotin residues at two edges of each well, just one streptavidin tetramer is size-selectively captured to form a regularly oriented streptavidin nanoarray. The anchored" tetramers nested in the wells are stable under repetitive AFM scanning. (Chemical Equation). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA."

引用

页码：3400 / 3402

页数：3

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