Highly enantio- and diastereoselective construction of 1,2-disubstituted cyclopentane compounds by dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate]-catalyzed C-H insertion reactions of α-diazo esters

被引：83

作者：

Minami, K ^{[1
]}

Saito, H ^{[1
]}

Tsutsui, H ^{[1
]}

Nambu, H ^{[1
]}

Anada, M ^{[1
]}

Hashimoto, S ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2005年 / 347卷 / 11-13期

关键词：

asymmetric catalysis; C-C bond formation; C-H insertion; chiral dirhodium(II) carboxylates; cyclization; alpha-diazo esters;

D O I：

10.1002/adsc.200505201

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A highly enantio- and diastereoselective intramolecular C-H insertion reaction of alpha-diazo esters has been achieved with the use of dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate] as a catalyst, providing exclusively cis-2-arylcyclopentane-1 -carboxylates in up to 95% ee with no evidence of alkene formation.

引用

页码：1483 / 1487

页数：5

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