Antioxidants do not explain the disparate longevity between mice and the longest-living rodent, the naked mole-rat

被引:116
作者
Andziak, B
O'Connor, TP
Buffenstein, R
机构
[1] CUNY City Coll, Dept Biol, New York, NY 10031 USA
[2] CUNY, Grad Ctr, New York, NY 10016 USA
[3] Weill Cornell Med Coll, Dept Med Genet, New York, NY 10021 USA
关键词
antioxidants; longevity; mice; naked mole-rats;
D O I
10.1016/j.mad.2005.06.009
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The maximum lifespan of naked mole-rats (NMRs; Heterocephalus glaber) is greater than that of any other rodent. These hystricognaths survive in captivity > 28 years, eight-times longer than similar-sized mice. The present study tested if NMRs possess superior antioxidant defenses compared to mice and if age-related interspecies changes in antioxidants were evident. Activities of Cu/Zn superoxide dismutase (Cu/Zn, SOD), Mn SOD, catalase and cellular glutathione peroxidase (cGPx) were measured in livers of physiologically equivalent age-matched NMRs (30, 75 and 130 months) and CB6F1 mice (4, 12 and 18 months). In mice, Mm SOD activity increased with age, while the activity of catalase and cGPx declined. None of the antioxidants changed with age in mole-rats. cGPx activity of NMRs was 70-times lower (p < 0.0001) than in mice, and resembled that of cGPx knock-out animals. NMRs may partially compensate for the lower cGPx when compared to mice, by having moderately higher activities of the other antioxidants. It is nonetheless unlikely that antioxidant defenses are responsible for the eight-fold longevity difference between these two species. Maintenance of constant antioxidant defenses with age in NMRs concurs with previous physiological data, suggesting delayed aging in this species. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:1206 / 1212
页数:7
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