Fourier transform capillary electrophoresis with Laminar-Flow gated pressure injection

被引：8

作者：

Allen, Peter B. ^{[1
]}

Doepker, Byron R. ^{[1
]}

Chiu, Daniel T. ^{[1
]}

机构：

[1] Univ Washington, Dept Chem, Seattle, WA 98195 USA

来源：

ANALYTICAL CHEMISTRY | 2007年 / 79卷 / 17期

关键词：

MICROCHIP ELECTROPHORESIS; VELOCITY-MEASUREMENTS; MICROFLUIDIC SYSTEMS; SAMPLE INJECTION; SHAH; CHIP; POLY(DIMETHYLSILOXANE); GENERATION; PARTICLES; SOLUTES;

D O I：

10.1021/ac0710026

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Fourier transform capillary electrophoresis (FTCE) was developed as a method to improve signal-to-noise ratio (S/N) and resolution in capillary electrophoresis (CE) separation. In FTCE, multiple simultaneous CE separations were performed in the same channel system and interrogated using a single-point detector. To illustrate experimentally the improvement offered by FTCE in S/N ratio and resolution, we carried out a modest number (five) of multiple injections and separations. We show even with this small number of separations, S/N increased by a factor of 2.9, and theoretical plate height improved by a factor of more than 30. We demonstrated this technique with laser-induced fluorescence detection, but a wide variety of detection methods are compatible with FTCE.

引用

页码：6807 / 6815

页数：9

共 31 条

[1] A capillary electrophoresis chip with hydrodynamic sample injection for measurements from a continuous sample flow [J].