Risk of hepatitis C virus transmission following percutaneous exposure in healthcare workers

被引:68
作者
De Carli, G [1 ]
Puro, V [1 ]
Ippolito, G [1 ]
机构
[1] Natl Inst Infect Dis, Lazzaro Spallanzani IRCCS, Dept Epidemiol, I-00149 Rome, Italy
关键词
D O I
10.1007/s15010-003-8230-8
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background: We wanted to determine the incidence of anti-hepatitis C virus (HCV) seroconversion after percutaneous exposure to infectious fluids of an anti-HCV positive source in healthcare workers (HCW) and to investigate related risk factors. Patients and Methods: Prospective observation in 55 Italian hospitals of anti-HCV-negative exposed HCW were followed clinically and serologically for at Least 6 months. Results: Of 4,403 exposed HCW, 14 seroconverted (0.31%; 95% CI 0.15-0.48) after an injury with a hollow-bore, blood-filled needle (14/1,876=0.74%; 95% CI 0.41-1.25). Deep injuries increased the seroconversion risk (OR 6.53; 95% CI 2.01-20.80). Exposure to an HIV co-infected source was associated with an higher, though not yet statistically significant, risk (OR 2.76, 95% CI 0.49-10.77). Source's HCV viremia was available in 674 cases, 566 of whom tested positive, including the nine seroconversion cases for whom this information was available. Conclusion: The risk of acquiring HCV after percutaneous exposure seems to be Lower than previously reported. Deep injury, injury with a blood-filled needle and HIV co-infection of source seem to be associated with occupational transmission. Needlestick prevention devices could decrease the risk of infection with HCV and other bloodborne pathogens in HCW.
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页码:22 / 27
页数:6
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