A novel asymmetric synthesis of 2,5-dialkylpyrrolidines

被引：13

作者：

Daley, V

D'Angelo, J

Cavé, C

Mahuteau, J

Chiaroni, A

Riche, C

机构：

[1] Univ Paris Sud, Ctr Etud Pharmaceut, CNRS, Unite Chim Organ Associee, F-92296 Chatenay Malabry, France

[2] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 09期

关键词：

D O I：

10.1016/S0040-4039(99)00058-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

ZnCl2-promoted cyclization of enamino eater 8 furnished a 1.5: 1 mixture of pyrrolidines 9 and 10. NaBH4-reduction of this mixture gave cis and trans-2,5-dialkylpyrrolidines 12 and 13 in the ratio 2:1. The latter derivative was obtained in its 2S, 5S enantiomerically pure form. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：1657 / 1660

页数：4

共 5 条

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