Synthesis of 5-arylhistidines via a Suzuki-Miyaura cross-coupling

被引：19

作者：

Cerezo, Vanessa ^{[1
]}

Afonso, Ana ^{[1
]}

Planas, Marta ^{[1
]}

Feliu, Lidia ^{[1
]}

机构：

[1] Univ Girona, Dept Quim, Lab Innovacio & Proc Prod Sintesis Org, Girona 17071, Spain

来源：

TETRAHEDRON | 2007年 / 63卷 / 42期

关键词：

histidine; arylation; Suzuki-Miyaura cross-coupling; microwave; biaryl compounds;

D O I：

10.1016/j.tet.2007.08.010

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Microwave irradiation efficiently promoted the Suzuki-Miyaura reaction of a 5-bromohistidine with various arylboronic acids in the presence of a palladium catalyst. This methodology allowed the synthesis of histidines substituted at position 5 of the imidazole ring with a phenyl, a substituted phenyl, a pyridyl or a thienyl ring. The corresponding 5-arylhistidines were obtained in moderate to good yields. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：10445 / 10453

页数：9

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