An efficient method for the N-debenzylation of aromatic heterocycles

被引：9

作者：

Rao, TS ^{[1
]}

Pandey, PS ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, New Delhi 110016, India

来源：

SYNTHETIC COMMUNICATIONS | 2004年 / 34卷 / 17期

关键词：

N-debenzylation; aromatic heterocycles; sodium in liquid; ammonia; substituted pyrroles;

D O I：

10.1081/SCC-200028570

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The N-debenzylation of aromatic heterocycles such as substituted pyrroles and indoles, having functional groups like ester, amide, halo, and nitrile, by using sodium in liquid ammonia in the presence of t-BuOH at -78degreesC cleanly affords N-debenzylated aromatic heterocycles in good yields.

引用

页码：3121 / 3127

页数：7

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