Aryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I

被引：29

作者：

Bergman, JM ^{[1
]}

Abrams, MT

Davide, JP

Greenberg, IB

Robinson, RG

Buser, CA

Huber, HE

Koblan, KS

Kohl, NE

Lobell, RB

Graham, SL

Hartman, GD

Williams, TM

Dinsmore, CJ

机构：

[1] Merck Res Labs, Dept Med Chem, W Point, PA 19486 USA

[2] Merck Res Labs, Dept Canc Res, W Point, PA 19486 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(01)00240-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of aryloxy substituted piperazinones with dual farnesyltransferase/geranylgeranyltransferase-I inhibitory activity was prepared. These compounds were found to have potent inhibitory activity in vitro and are promising agents for the inhibition of Ki-Ras signaling. (C) 2001 Published by Elsevier Science Ltd. All rights reserved.

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页码：1411 / 1415

页数：5

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