Interdependence of mycobacterial iron regulation, oxidative-stress response and isoniazid resistance

被引：34

作者：

Dussurget, O

Smith, I

机构：

[1] Publ Hlth Res Inst, New York, NY 10016 USA

[2] Univ Paris 07, UFR Biochim, F-75251 Paris 05, France

来源：

TRENDS IN MICROBIOLOGY | 1998年 / 6卷 / 09期

关键词：

D O I：

10.1016/S0966-842X(98)01307-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Iron is an essential cofactor for vital functions in microorganisms. Bacterial pathogens have developed efficient iron-acquisition systems to counteract the defensive sequestration of iron by their hosts. In mycobacteria, the recently described protein, IdeR, negatively controls iron-uptake systems. This protein also has a role in the oxidative-stress response, as well as in resistance to the frontline antimycobacterial drug isoniazid.

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页码：354 / 358

页数：5

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