Cyclohexenonic long-chain fatty alcohols as neuronal growth stimulators

被引:33
作者
Luu, B
de Aguilar, JLG
Girlanda-Junges, C
机构
[1] Univ Strasbourg, Lab Chim Organ Substances Nat, UMR CNRS 7509, Ctr Neurochim, F-67084 Strasbourg, France
[2] Univ Strasbourg, Lab Neurophysiol Cellulaire & Integree, UMR CNRS 7519, F-67084 Strasbourg, France
来源
MOLECULES | 2000年 / 5卷 / 12期
关键词
cyclohexenonic long-chain fatty alcohol; neurite outgrowth; neuronal survival; neurotrophic compound; neurotrophic factor; NGF; synthesis;
D O I
10.3390/51201439
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Neurotrophic factors play an important role in the development and maintenance of neurons, thus providing a suitable therapeutic approach for the treatment of neurodegenerative diseases. However, their clinical use has revealed problematic because of a number of technical and biological disadvantages. Among the different strategies proposed to overcome such difficulties, the search for non-peptide substances with neurotrophic potential is giving promising results. Here we will expose major findings in this field, drawing special attention to cyclohexenonic long-chain fatty alcohols, a novel family of compounds that promote neuronal survival and neurite outgrowth.
引用
收藏
页码:1439 / 1460
页数:22
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