共 82 条
Cyclohexenonic long-chain fatty alcohols as neuronal growth stimulators
被引:33
作者:
Luu, B
de Aguilar, JLG
Girlanda-Junges, C
机构:
[1] Univ Strasbourg, Lab Chim Organ Substances Nat, UMR CNRS 7509, Ctr Neurochim, F-67084 Strasbourg, France
[2] Univ Strasbourg, Lab Neurophysiol Cellulaire & Integree, UMR CNRS 7519, F-67084 Strasbourg, France
来源:
MOLECULES
|
2000年
/
5卷
/
12期
关键词:
cyclohexenonic long-chain fatty alcohol;
neurite outgrowth;
neuronal survival;
neurotrophic compound;
neurotrophic factor;
NGF;
synthesis;
D O I:
10.3390/51201439
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Neurotrophic factors play an important role in the development and maintenance of neurons, thus providing a suitable therapeutic approach for the treatment of neurodegenerative diseases. However, their clinical use has revealed problematic because of a number of technical and biological disadvantages. Among the different strategies proposed to overcome such difficulties, the search for non-peptide substances with neurotrophic potential is giving promising results. Here we will expose major findings in this field, drawing special attention to cyclohexenonic long-chain fatty alcohols, a novel family of compounds that promote neuronal survival and neurite outgrowth.
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页码:1439 / 1460
页数:22
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