The functional BDNF Val66Met polymorphism affects functions of pre-attentive visual sensory memory processes

被引：25

作者：

Beste, Christian ^{[1
]}

Schneider, Daniel ^{[1
]}

Epplen, Joerg T. ^{[2
]}

Arning, Larissa ^{[2
]}

机构：

[1] Ruhr Univ Bochum, Inst Cognit Neurosci, Dept Biopsychol, D-44780 Bochum, Germany

[2] Ruhr Univ Bochum, Dept Human Genet, Fac Med, D-44780 Bochum, Germany

来源：

NEUROPHARMACOLOGY | 2011年 / 60卷 / 2-3期

关键词：

BDNF Val66Met polymorphism; Cognition; Depression; Iconic memory; Sensory memory; NEUROTROPHIC FACTOR LEVELS; ACTIVITY-DEPENDENT SECRETION; BASAL FOREBRAIN NEURONS; MISMATCH NEGATIVITY; DEPRESSED-PATIENTS; ICONIC MEMORY; SERUM; ASSOCIATION; SCHIZOPHRENIA; RAT;

D O I：

10.1016/j.neuropharm.2010.10.028

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, is involved in nerve growth and survival. Especially, a single nucleotide polymorphism (SNP) in the BDNF gene, Val66Met, has gained a lot of attention, because of its effect on activity-dependent BDNF secretion and its link to impaired memory processes. We hypothesize that the BDNF Val66Met polymorphism may have modulatory effects on the visual sensory (iconic) memory performance. Two hundred and eleven healthy German students (106 female and 105 male) were included in the data analysis. Since BDNF is also discussed to be involved in the pathogenesis of depression, we additionally tested for possible interactions with depressive mood. The BDNF Val66Met polymorphism significantly influenced iconic-memory performance, with the combined Val/Met-Met/Met genotype group revealing less time stability of information stored in iconic memory than the Val/Val group. Furthermore, this stability was positively correlated with depressive mood exclusively in the Val/Val genotype group. Thus, these results show that the BDNF Val66Met polymorphism has an effect on pre-attentive visual sensory memory processes. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：467 / 471

页数：5

共 42 条

[31] NR2A but not NR2B N-methyl-D-aspartate receptor subunit is altered in the visual cortex of BDNF-knock-out mice [J].