Sitagliptin Manufacture: A Compelling Tale of Green Chemistry, Process Intensification, and Industrial Asymmetric Catalysis

被引：148

作者：

Desai, Aman A. ^{[1
]}

机构：

[1] Dow Chem Co USA, Proc Chem & Dev, Core R&D, Midland, MI 48674 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 09期

关键词：

asymmetric catalysis; biocatalysis; green chemistry; process chemistry; sitagliptin; IV INHIBITOR; HYDROGENATION;

D O I：

10.1002/anie.201007051

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Generation gap: Three generations of process research and development towards the industrial manufacture of sitagliptin phosphate (1), a leading drug for type2 diabetes, are highlighted. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1974 / 1976

页数：3

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