The what, where, how and why of gene ontology-a primer for bioinformaticians

被引：97

作者：

du Plessis, Louis ^{[1
]}

Skunca, Nives ^{[1
]}

Dessimoz, Christophe ^{[1
]}

机构：

[1] ETH, CBRG Grp, CH-8092 Zurich, Switzerland

来源：

BRIEFINGS IN BIOINFORMATICS | 2011年 / 12卷 / 06期

关键词：

gene ontology; gene annotation; semantic similarity; gene function; function prediction; PROTEIN-INTERACTION; GO DATABASE; ANNOTATION; PREDICTION; SEQUENCE; SIMILARITY; GENOMES; ACCESS;

D O I：

10.1093/bib/bbr002

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

With high-throughput technologies providing vast amounts of data, it has become more important to provide systematic, quality annotations. The Gene Ontology (GO) project is the largest resource for cataloguing gene function. Nonetheless, its use is not yet ubiquitous and is still fraught with pitfalls. In this review, we provide a short primer to the GO for bioinformaticians. We summarize important aspects of the structure of the ontology, describe sources and types of functional annotations, survey measures of GO annotation similarity, review typical uses of GO and discuss other important considerations pertaining to the use of GO in bioinformatics applications.

引用

页码：723 / 735

页数：13

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