In situ hybridization of PNA/DNA studied label-free by electrochemical impedance spectroscopy

被引：85

作者：

Liu, JY

Tian, SJ

Nielsen, PE

Knoll, W

机构：

[1] Max Planck Inst Polymer Res, D-55128 Mainz, Germany

[2] Univ Copenhagen, Panum Inst, Ctr Biochem Recognit, Dept Biochem & Genet,Biochem Lab B, DK-2200 Copenhagen, Denmark

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 23期

关键词：

D O I：

10.1039/b419425j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The in situ hybridization kinetics of label-free DNA on mixed monolayers of peptide nucleic acid (PNA) and 6-mercapto-1-hexanol (MCH) on Au electrodes was investigated by electrochemical impedance spectroscopy (EIS) and used to discriminate the fully complementary DNA from the single-base mismatched hybrids.

引用

收藏

页码：2969 / 2971

页数：3

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