DNA replication: Building the perfect switch

被引：81

作者：

Diffley, JFX ^{[1
]}

机构：

[1] Imperial Canc Res Fund, Clare Hall Labs, S Mimms EN6 3LD, Herts, England

来源：

CURRENT BIOLOGY | 2001年 / 11卷 / 09期

关键词：

D O I：

10.1016/S0960-9822(01)00196-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

a sophisticated molecular switch ensures that replication origins are activated just once in each cell cycle. Recent work reveals how the proteolysis of a key replication inhibitor, geminin, by the anaphase promoting complex/cyclosome is an important component of this switch.

引用

页码：R367 / R370

页数：4

共 30 条

[11] Fission yeast WD-repeat protein Pop1 regulates genome ploidy through ubiquitin-proteasome-mediated degradation of the CDK inhibitor Rum1 and the S-phase initiator Cdc18
Kominami, K
Toda, T
[J]. GENES & DEVELOPMENT, 1997, 11 (12) : 1548 - 1560
[12] G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus
Labib, K
Diffley, JFX
Kearsey, SE
[J]. NATURE CELL BIOLOGY, 1999, 1 (07) : 415 - 422
[13] Is the MCM2-7 complex the eukaryotic DNA replication fork helicase?
Labib, K
Diffley, JF
[J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 2001, 11 (01) : 64 - 70
[14] XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis
Maiorano, D
Moreau, J
Méchali, M
[J]. NATURE, 2000, 404 (6778) : 622 - 625
[15] Geminin, an inhibitor of DNA replication, is degraded during mitosis
McGarry, TJ
Kirschner, MW
[J]. CELL, 1998, 93 (06) : 1043 - 1053
[16] Chromatin association of human origin recognition complex, Cdc6, and minichromosome maintenance proteins during the cell cycle:: Assembly of prereplication complexes in late mitosis
Méndez, J
Stillman, B
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (22) : 8602 - 8612
[17] Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7
Nguyen, VQ
Co, C
Irie, K
Li, JJ
[J]. CURRENT BIOLOGY, 2000, 10 (04) : 195 - 205
[18] The Cdt1 protein is required to license DNA for replication in fission yeast
Nishitani, H
Lygerou, Z
Nishimoto, T
Nurse, P
[J]. NATURE, 2000, 404 (6778) : 625 - +
[19] CDK inactivation is the only essential function of the APC/C and the mitotic exit network proteins for origin resetting during mitosis
Noton, E
Diffley, JFX
[J]. MOLECULAR CELL, 2000, 5 (01) : 85 - 95
[20] Oshiro G, 1999, MOL CELL BIOL, V19, P4888

← 1 2 3 →