Diffusion tensor imaging in schizophrenia: Relationship to symptoms

被引:102
作者
Skelly, Laurie R. [1 ]
Calhoun, Vince [1 ,2 ,3 ,4 ]
Meda, Shashwath A. [1 ]
Kim, Jinsuh [5 ]
Mathalon, Daniel H. [2 ]
Pearlson, Godfrey D. [1 ]
机构
[1] Inst Living, Olin Neuropsychiat Res Ctr, Hartford, CT 06106 USA
[2] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA
[3] MIND Inst, Albuquerque, NM 87131 USA
[4] Univ New Mexico, Dept ECE, Albuquerque, NM 87131 USA
[5] Univ Iowa, Dept Radiol, Iowa City, IA 52246 USA
关键词
diffusion tensor imaging; fractional anisotropy; schizophrenia; positive symptoms; disconnection hypothesis;
D O I
10.1016/j.schres.2007.10.009
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
In this diffusion tensor imaging (DTI) study, the authors investigated white matter integrity in schizophrenia and the relationships between white matter alterations and specific symptoms of the disorder. We compared DTI images of 25 schizophrenia patients and 25 matched healthy controls and performed voxel-wise correlational analyses using the patient's DTI data and their severity scores of positive and negative symptoms. We found diffuse deficits in multiple types of white matter tracts in schizophrenia, and an inverse relationship of DTI fractional anisotropy (FA) values with positive symptom scores in association fibers, supporting a "disconnection" hypothesis of positive symptoms in schizophrenia. (C) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码:157 / 162
页数:6
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