microPrimer: The biogenesis and function of microRNA

被引：638

作者：

Du, TT ^{[1
]}

Zamore, PD ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Mol Pharmacol & Biochem, Worcester, MA 01605 USA

来源：

DEVELOPMENT | 2005年 / 132卷 / 21期

关键词：

D O I：

10.1242/dev.02070

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Discovered in nematodes in 1993, microRNAs (miRNAs) are non-coding RNAs that are related to small interfering RNAs (siRNAs), the small RNAs that guide RNA interference (RNAi). miRNAs sculpt gene expression profiles during plant and animal development. In fact, miRNAs may regulate as many as one-third of human genes. miRNAs are found only in plants and animals, and in the viruses that infect them. miRNAs function very much like siRNAs, but these two types of small RNAs can be distinguished by their distinct pathways for maturation and by the logic by which they regulate gene expression.

引用

页码：4645 / 4652

页数：8

共 142 条

[41] A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA [J].

Hutvágner, G ;

McLachlan, J ;

Pasquinelli, AE ;

Bálint, É ;

Tuschl, T ;

Zamore, PD .

SCIENCE, 2001, 293 (5531) :834-838

[42] Sequence-specific inhibition of small RNA function [J].

Hutvágner, G ;

Simard, MJ ;

Mello, CC ;

Zamore, PD .

PLOS BIOLOGY, 2004, 2 (04) :465-475

[43] A microRNA in a multiple-turnover RNAi enzyme complex [J].

Hutvágner, G ;

Zamore, PD .

SCIENCE, 2002, 297 (5589) :2056-2060

[44] A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins [J].

Ishizuka, A ;

Siomi, MC ;

Siomi, H .

GENES & DEVELOPMENT, 2002, 16 (19) :2497-2508

[45] Dicer-1 and R3D1-L catalyze microRNA maturation in Drosophila [J].

Jiang, F ;

Ye, XC ;

Liu, X ;

Fincher, L ;

McKearin, D ;

Liu, QH .

GENES & DEVELOPMENT, 2005, 19 (14) :1674-1679

[46] Involvement of MicroRNA in AU-rich element-mediated mRNA instability [J].

Jing, Q ;

Huang, S ;

Guth, S ;

Zarubin, T ;

Motoyama, A ;

Chen, JM ;

Di Padova, F ;

Lin, SC ;

Gram, H ;

Han, JH .

CELL, 2005, 120 (05) :623-634

[47] Computational identification of plant MicroRNAs and their targets, including a stress-induced miRNA [J].

Jones-Rhoades, MW ;

Bartel, DP .

MOLECULAR CELL, 2004, 14 (06) :787-799

[48] Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C-elegans [J].

Ketting, RF ;

Fischer, SEJ ;

Bernstein, E ;

Sijen, T ;

Hannon, GJ ;

Plasterk, RHA .

GENES & DEVELOPMENT, 2001, 15 (20) :2654-2659

[49]

Khvorova A, 2003, CELL, V115, P209, DOI 10.1016/S0092-8674(03)00801-8

[50] The developmental role of microRNA in plants [J].

Kidner, CA ;

Martienssen, RA .

CURRENT OPINION IN PLANT BIOLOGY, 2005, 8 (01) :38-44

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