Chasing the proton culprit from palladium-catalyzed allylic amination

被引：81

作者：

Dubovyk, Igor ^{[1
]}

Watson, Iain D. G. ^{[1
]}

Yudin, Andrei K. ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, Davenport Res Labs, Toronto, ON M5S 3H6, Canada

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 46期

关键词：

D O I：

10.1021/ja076659n

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have found that the addition of base has a significant effect on palladium-catalyzed allylic amination. The long-standing problem of controlling the branched-to-linear ratio has been solved. In the presence of DBU and inexpensive, readily available ligands, palladium-catalyzed allylation proceeds under kinetic control, leading to high branched selectivity. Given the widespread utility of palladium-catalyzed allylic amination, we expect that these findings will be relevant in many areas ranging from asymmetric catalysis to target-oriented synthesis.

引用

页码：14172 / +

页数：3

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