New functionalised silicas for highly selective cation exchange SPE purification in medicinal chemistry

被引：8

作者：

Brown, Jane ^{[2
]}

Chighine, Alessandra ^{[1
]}

Colucci, Marie A. ^{[2
]}

Galaffu, Nicola ^{[1
]}

Hirst, Simon C. ^{[2
]}

Seymour, Helen M. ^{[1
]}

Shiers, Jason J. ^{[2
]}

Wilkes, Robin D. ^{[1
]}

Williams, Jonathan G. ^{[2
]}

Wilson, John R. H. ^{[1
]}

机构：

[1] PhosphonicS Ltd, Abingdon OX14 4SA, Oxon, England

[2] Sygnat Chem Serv Ltd, Nottingham NG1 1GF, England

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 33期

关键词：

solid phase extraction (SPE); cation exchange; SCX; amine separation; purification; functionalised silica; immobilised acid;

D O I：

10.1016/j.tetlet.2008.05.087

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Functionalised silicas 2 and 3 are effective for the cation exchange SPE purification of basic molecules containing acid-sensitive functionalities, the selective separations of mixtures of basic compounds and accelerated reaction work-ups/product isolations. (C) 2008 Elsevier Ltd. All rights reserved.

引用

收藏

页码：4968 / 4971

页数：4

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