Biogenic amine neurotransmitter transporters: Just when you thought you knew them

被引:62
作者
Blakely, RD [1 ]
DeFelice, LJ
Galli, A
机构
[1] Vanderbilt Univ, Sch Med, Dept Pharmacol, Nashville, TN 37212 USA
[2] Vanderbilt Univ, Sch Med, Dept Mol Physiol, Nashville, TN 37212 USA
[3] Vanderbilt Univ, Sch Med, Dept Biophys, Nashville, TN 37212 USA
[4] Vanderbilt Univ, Sch Med, Dept Psychiat, Nashville, TN 37212 USA
[5] Vanderbilt Univ, Sch Med, Ctr Mol Neurosci, Nashville, TN 37212 USA
关键词
D O I
10.1152/physiol.00013.2005
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Plasma membrane transporters have long been known to support the reuptake of biogenic amine neurotransmitters following release in the central and peripheral nervous systems. Using high-resolution imaging, patch-clamp and amperometric approaches, as well as molecular manipulations of transporter-regulatory pathways, surprising new details have been uncovered as to how transporters work and are influenced by signaling pathways and psychostimulants.
引用
收藏
页码:225 / 231
页数:7
相关论文
共 59 条
  • [11] Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A
    Deken, SL
    Beckman, ML
    Boos, L
    Quick, MW
    [J]. NATURE NEUROSCIENCE, 2000, 3 (10) : 998 - 1003
  • [12] Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission
    Floresco, SB
    West, AR
    Ash, B
    Moore, H
    Grace, AA
    [J]. NATURE NEUROSCIENCE, 2003, 6 (09) : 968 - 973
  • [13] Dopamine transporters are phosphorylated on N-terminal serines in rat striatum
    Foster, JD
    Pananusorn, B
    Vaughan, RA
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (28) : 25178 - 25186
  • [14] Serotonin transporter function in vivo:: Assessment by chronoamperometry
    Frazer, A
    Daws, LC
    [J]. ADVANCES IN SEROTONIN RECEPTOR RESEARCH: MOLECULAR BIOLOGY, SIGNAL TRANSDUCTION, AND THERAPEUTICS, 1998, 861 : 217 - 229
  • [15] Monoamine transporters: From genes to behavior
    Gainetdinov, RR
    Caron, MG
    [J]. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2003, 43 : 261 - 284
  • [16] GALLI A, 1995, J EXP BIOL, V198, P2197
  • [17] Galli A, 1997, J NEUROSCI, V17, P3401
  • [18] Patch-clamp and amperometric recordings from norepinephrine transporters: Channel activity and voltage-dependent uptake
    Galli, A
    Blakely, RD
    DeFelice, LJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (22) : 13260 - 13265
  • [19] Norepinephrine transporters have channel modes of conduction
    Galli, A
    Blakely, RD
    DeFelice, LJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (16) : 8671 - 8676
  • [20] GOLDBERG NR, 2003, STRATEGIES MOL NEURO