Biogenic amine neurotransmitter transporters: Just when you thought you knew them

被引：62

作者：

Blakely, RD ^{[1
]}

DeFelice, LJ

Galli, A

机构：

[1] Vanderbilt Univ, Sch Med, Dept Pharmacol, Nashville, TN 37212 USA

[2] Vanderbilt Univ, Sch Med, Dept Mol Physiol, Nashville, TN 37212 USA

[3] Vanderbilt Univ, Sch Med, Dept Biophys, Nashville, TN 37212 USA

[4] Vanderbilt Univ, Sch Med, Dept Psychiat, Nashville, TN 37212 USA

[5] Vanderbilt Univ, Sch Med, Ctr Mol Neurosci, Nashville, TN 37212 USA

来源：

PHYSIOLOGY | 2005年 / 20卷

关键词：

D O I：

10.1152/physiol.00013.2005

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Plasma membrane transporters have long been known to support the reuptake of biogenic amine neurotransmitters following release in the central and peripheral nervous systems. Using high-resolution imaging, patch-clamp and amperometric approaches, as well as molecular manipulations of transporter-regulatory pathways, surprising new details have been uncovered as to how transporters work and are influenced by signaling pathways and psychostimulants.

引用

页码：225 / 231

页数：7

共 59 条

[31] N-terminal phosphorylation of the dopamine transporter is required for amphetamine-induced efflux
Khoshbouei, H
Sen, N
Guptaroy, B
Johnson, L
Lund, D
Gnegy, ME
Galli, A
Javitch, JA
[J]. PLOS BIOLOGY, 2004, 2 (03): : 387 - 393
[32] Listening to neurotransmitter transporters
Lester, HA
Cao, YW
Mager, S
[J]. NEURON, 1996, 17 (05) : 807 - 810
[33] Single-channel currents produced by the serotonin transporter and analysis of a mutation affecting ion permeation
Lin, F
Lester, HA
Mager, S
[J]. BIOPHYSICAL JOURNAL, 1996, 71 (06) : 3126 - 3135
[34] The dopamine transporter constitutively internalizes and recycles in a protein kinase C-regulated manner in stably transfected PC12 cell lines
Loder, MK
Melikian, HE
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (24) : 22168 - 22174
[35] CONDUCTING STATES OF A MAMMALIAN SEROTONIN TRANSPORTER
MAGER, S
MIN, C
HENRY, DJ
CHAVKIN, C
HOFFMAN, BJ
DAVIDSON, N
LESTER, HA
[J]. NEURON, 1994, 12 (04) : 845 - 859
[36] Partitioning of the serotonin transporter into lipid microdomains modulates transport of serotonin
Magnani, F
Tate, CG
Wynne, S
Williams, C
Haase, J
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (37) : 38770 - 38778
[37] Novel fluorescence-based approaches for the study of biogenic amine transporter localization, activity, and regulation
Mason, JN
Farmer, H
Tomlinson, ID
Schwartz, JW
Savchenko, V
DeFelice, LJ
Rosenthal, SJ
Blakely, RD
[J]. JOURNAL OF NEUROSCIENCE METHODS, 2005, 143 (01) : 3 - 25
[38] Mehrens T, 2000, J AM SOC NEPHROL, V11, P1216, DOI 10.1681/ASN.V1171216
[39] Pierce RC, 1997, J NEUROSCI, V17, P3254
[40] Pierce RC, 1998, NEUROSCIENCE, V82, P1103

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