Biogenic amine neurotransmitter transporters: Just when you thought you knew them

被引:62
作者
Blakely, RD [1 ]
DeFelice, LJ
Galli, A
机构
[1] Vanderbilt Univ, Sch Med, Dept Pharmacol, Nashville, TN 37212 USA
[2] Vanderbilt Univ, Sch Med, Dept Mol Physiol, Nashville, TN 37212 USA
[3] Vanderbilt Univ, Sch Med, Dept Biophys, Nashville, TN 37212 USA
[4] Vanderbilt Univ, Sch Med, Dept Psychiat, Nashville, TN 37212 USA
[5] Vanderbilt Univ, Sch Med, Ctr Mol Neurosci, Nashville, TN 37212 USA
关键词
D O I
10.1152/physiol.00013.2005
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Plasma membrane transporters have long been known to support the reuptake of biogenic amine neurotransmitters following release in the central and peripheral nervous systems. Using high-resolution imaging, patch-clamp and amperometric approaches, as well as molecular manipulations of transporter-regulatory pathways, surprising new details have been uncovered as to how transporters work and are influenced by signaling pathways and psychostimulants.
引用
收藏
页码:225 / 231
页数:7
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