TGF-β/BAMBI pathway dysfunction contributes to peripheral Th17/Treg imbalance in chronic obstructive pulmonary disease

被引：48

作者：

Zhang, Jian-Chu ^{[1
]}

Chen, Gang ^{[1
]}

Chen, Long ^{[1
]}

Meng, Zhao-Ji ^{[1
]}

Xiong, Xian-Zhi ^{[1
]}

Liu, Hong-Ju ^{[1
]}

Jin, Yang ^{[1
]}

Tao, Xiao-Nan ^{[1
]}

Wu, Jiang-Hua ^{[1
]}

Sun, Sheng-Wen ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Union Hosp, Dept Resp Med, Tongji Med Coll, 1277 JieFang Ave, Wuhan 430022, Peoples R China

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

基金：

中国国家自然科学基金;

关键词：

REGULATORY T-CELLS; GROWTH-FACTOR-BETA; BOUND INHIBITOR BAMBI; PSEUDORECEPTOR BAMBI; MESSENGER-RNA; TH17; CELLS; EXPRESSION; BLOOD; BMP; ADIPOGENESIS;

D O I：

10.1038/srep31911

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

BMP and activin membrane-bound inhibitor (BAMBI) is postulated to inhibit or modulate transforming growth factor beta (TGF-beta) signaling. Furthermore, strong upregulation of BAMBI expression following in vitro infection of chronic obstructive pulmonary disease (COPD) lung tissue has been demonstrated. In this study, we investigated whether TGF-beta/BAMBI pathway is associated with COPD. Blood samples were obtained from 27 healthy controls (HC), 24 healthy smokers (HS) and 29 COPD patients. Elevated Th17/Treg ratios, and increased levels of BAMBI protein and mRNA (in plasma and CD4(+) T cells respectively), were observed in COPD compared with HC and HS. BAMBI expression was first observed on human CD4(+) T cells, with a typical membrane-bound pattern. The enhanced plasma BAMBI levels in COPD positively correlated with the increased plasma TGF-beta 1 levels and Th17/Treg ratio. Together, an impaired TGF-beta/BAMBI pathway may promote the inflammation leading to Th17/Treg imbalance, which is a new mechanism in smokers who develop COPD.

引用

页数：11

共 55 条

[1]

TGFβ signaling in health and disease [J].