Rapid analysis of pentazocine in human plasma by liquid chromatography/mass spectrometry with sonic spray ionization

被引：13

作者：

Arinobu, T

Hattori, H

Ishii, A

Kumazawa, T

Lee, XP

Kojima, S

Suzuki, O

Seno, H ^{[1
]}

机构：

[1] Aichi Med Univ, Sch Med, Dept Legal Med, Nagakute, Aichi 4801195, Japan

[2] Fujita Hlth Univ, Sch Med, Dept Legal Med, Toyoake, Aichi 4701192, Japan

[3] Showa Univ, Sch Med, Dept Legal Med, Shinagawa Ku, Tokyo 1428555, Japan

[4] Aichi Med Univ, Sch Med, Dept Chem, Nagakute, Aichi 4801195, Japan

[5] Hamamatsu Univ Sch Med, Dept Legal Med, Hamamatsu, Shizuoka 4313192, Japan

来源：

ANALYTICA CHIMICA ACTA | 2003年 / 492卷 / 1-2期

关键词：

pentazocine; LC/MS; sonic spray ionization; oasis HLB cartridge column;

D O I：

10.1016/S0003-2670(03)00893-6

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A rapid determination method for pentazocine in human plasma without complicated pretreatments has been constructed by liquid chromatography/mass spectrometry (LUMS) with sonic spray ionization (SSI) using an Oasis HLB cartridge column. The reliability on our method was investigated for human plasma samples spiked with pentazocine and dextromethorphan as internal standard. The regression equation for pentazocine showed good linearity in the ranges of 30-1,250 and 1,250-10,000 ng ml(-1); the detection limit was 19.5 ng ml(-1) in human plasma. The sensitivity, accuracy and precision were satisfactory to quantify the wide range of therapeutic to toxic levels. Our method established enabled the determination of a single sample of pentazocine in human plasma only within 4 min, and allowed analysis of more than 100 samples per day. The present method seems applicable for actual cases encountered in the forensic and clinical practices. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：249 / 252

页数：4

共 19 条

[1] Comparison of sonic spray ionization with atmospheric pressure chemical ionization as an interface of liquid chromatography - Mass Spectrometry for the analysis of some local anesthetics [J].