Synthesis of Azaheterocycles from Aryl Ketone O-Acetyl Oximes and Internal Alkynes by Cu-Rh Bimetallic Relay Catalysts

被引：219

作者：

Too, Pei Chui ^{[1
]}

Chua, Sze Hui ^{[1
]}

Wong, Siong Heng ^{[1
]}

Chiba, Shunsuke ^{[1
]}

机构：

[1] Nanyang Technol Univ, Div Chem & Biol Chem, Sch Phys & Math Sci, Singapore 637371, Singapore

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 76卷 / 15期

关键词：

H BOND FUNCTIONALIZATION; ONE-POT SYNTHESIS; AROMATIC IMINES; OXIDATIVE COUPLING/CYCLIZATION; CARBON-HYDROGEN; ACTIVATION; ANNULATION; DERIVATIVES; ALKYLATION; ARYLATION;

D O I：

10.1021/jo200897q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthetic method for azaheterocycles from aryl ketone O-acetyl oximes and internal alkynes has been developed by using the Cu(OAc)(2)-[Cp*RhCl2](2) bimetallic catalytic system. The reactions proceeded with both of anti- and syn-isomers of oximes with a wide scope of substituents. The Cu Rh bimetallic system could be applied for the synthesis of isoquinolines as well as beta-carboline, furo[2.3-c]pyridine, pyrrolo[2,3-c]pyridine, and thieno[2,3-c]pyridine derivatives.

引用

页码：6159 / 6168

页数：10

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