Simultaneous determination of irbesartan and hydrochlorothiazide in tablets by derivative spectrophotometry

被引：20

作者：

Joseph-Charles, J ^{[1
]}

Brault, S ^{[1
]}

Boyer, C ^{[1
]}

Langlois, MH ^{[1
]}

Cabrero, L ^{[1
]}

Dubost, JP ^{[1
]}

机构：

[1] Univ Victor Segalen Bordeaux 2, UFR Sci Pharmaceut, Chim Analyt Lab, F-33076 Bordeaux, France

来源：

ANALYTICAL LETTERS | 2003年 / 36卷 / 11期

关键词：

irbesartan; hydrochlorothiazide; derivative spectrophotometry; simultaneous determination; tablets;

D O I：

10.1081/AL-120024337

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A second-derivative spectrophotometric method for the simultaneous determination of irbesartan (IRB) and hydrochlorothiazide (HCT) in tablets is described. Measurements were made at the zero-crossing wavelengths at 230.1 nm for IRB and 232.7 nm for HCT. The calibration graphs were linear in the range of 14.4-33.6 mg L-1 for IRB and 1.2-2.8 mg L-1 for HCT. The limits of quantitation were 5.0 and 1.1 mg L-1. The proposed method was successfully applied to the simultaneous determination of IRB and HCT in commercial tablets with a high percentage of recovery, good accuracy, and precision.

引用

页码：2485 / 2495

页数：11

共 26 条

[1] Determination of irbesartan in the presence of hydrochlorothiazide by derivative spectrophotometry [J].

Albero, I ;

Ródenas, V ;

García, S ;

Sánchez-Pedreño, C .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2002, 29 (1-2) :299-305

[2] The new angiotensin II receptor antagonist, irbesartan - Pharmacokinetic and pharmacodynamic considerations [J].

Brunner, HR .

AMERICAN JOURNAL OF HYPERTENSION, 1997, 10 (12) :311S-317S

[3] Angiotensin II receptor antagonists [J].

Burnier, M ;

Brunner, HR .

LANCET, 2000, 355 (9204) :637-645

[4] Simultaneous determination of losartan and hydrochlorothiazide in tablets by high-performance liquid chromatography [J].

Carlucci, G ;

Palumbo, G ;

Mazzeo, P ;

Quaglia, MG .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2000, 23 (01) :185-189

[5] High-performance liquid chromatographic assay for the quantitation of irbesartan (SR 47436 BMS-186295) in human plasma and urine [J].

Chang, SY ;

Whigan, DB ;

Vachharajani, NN ;

Patel, R .

JOURNAL OF CHROMATOGRAPHY B, 1997, 702 (1-2) :149-155

[6] SIMPLE DETERMINATION OF HYDROCHLOROTHIAZIDE IN HUMAN PLASMA AND URINE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

DEVRIES, JX ;

VOSS, A .

BIOMEDICAL CHROMATOGRAPHY, 1993, 7 (01) :12-14

[7] Determination of active ingredients in the pharmaceutical formulations containing hydrochlorothiazide and its binary mixtures with benazepril hydrochloride, triamterene and cilazapril by ratio spectra derivative spectrophotometry and vierordt's method [J].

Erk, N .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1999, 20 (1-2) :155-167

[8] Simultaneous determination of irbesartan and hydrochlorothiazide in human plasma by liquid chromatography [J].

Erk, N .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2003, 784 (01) :195-201

[9] Simple method for determination of hydrochlorothiazide in human urine by high performance liquid chromatography utilizing narrowbore chromatography [J].

Farthing, D ;

Fakhry, I ;

Ripley, EBD ;

Sica, D .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1998, 17 (08) :1455-1459

[10]

González L, 2002, ELECTROPHORESIS, V23, P223, DOI 10.1002/1522-2683(200202)23:2<223::AID-ELPS223>3.0.CO

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