Recent origin of Plasmodium falciparum from a single progenitor

被引:125
作者
Volkman, SK
Barry, AE
Lyons, EJ
Nielsen, KM
Thomas, SM
Choi, M
Thakore, SS
Day, KP
Wirth, DF
Hartl, DL
机构
[1] Harvard Univ, Sch Publ Hlth, Harvard Oxford Genome Divers Project, Boston, MA 02115 USA
[2] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
[3] Univ Oxford, Dept Zool, Oxford OX1 3PS, England
[4] Harvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 02138 USA
[5] Norwegian Univ Sci & Technol, Dept Bot, N-7491 Trondheim, Norway
关键词
D O I
10.1126/science.1059878
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Genetic variability of Plasmodium falciparum underlies its transmission success and thwarts efforts to control disease caused by this parasite. Genetic variation in antigenic, drug resistance, and pathogenesis determinants is abundant, consistent with an ancient origin of P. falciparum, whereas DNA variation at silent (synonymous) sites in coding sequences appears virtually absent, consistent with a recent origin of the parasite. To resolve this paradox, we analyzed introns and demonstrated that these are deficient in single-nucleotide polymorphisms, as are synonymous sites in coding regions. These data establish the recent origin of P. falciparum and further provide an explanation for the abundant diversity observed in antigen and other selected genes.
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收藏
页码:482 / 484
页数:3
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