Synthesis, biodistribution and micro-PET imaging of radiolabeled antimitotic agent T138067 analogues

被引：8

作者：

Fei, XS

Zheng, QH ^{[1
]}

Wang, JQ

Stone, KL

Martinez, TD

Miller, KD

Sledge, GW

Hutchins, GD

机构：

[1] Indiana Univ, Sch Med, Dept Radiol, Indianapolis, IN 46202 USA

[2] Indiana Univ, Sch Med, Dept Med, Indianapolis, IN 46202 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 05期

关键词：

D O I：

10.1016/j.bmcl.2003.12.061

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Radiolabeled antimitotic agents [C-11]T138067 and [F-18]T138067 have been synthesized for evaluation as new potential positron emission tomography (PET) biomarkers for cancer imaging. In vivo biodistribution and micro-PET imaging of [C-11]T138067 were performed in breast cancer animal models MCF-7 transfected with IL-1alpha implanted athymic mice and MDA-MB-435 implanted athymic mice. The results suggest that the uptakes of [C-11]T138067 in both MCF-7 transfected with IL-1alpha tumor and MDA-MB-435 tumor are non-specific binding. (C) 2003 Elsevier Ltd. All rights reserved.

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收藏

页码：1247 / 1251

页数：5

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