Genetics of morphogen gradients

被引：100

作者：

Tabata, T ^{[1
]}

机构：

[1] Univ Tokyo, Inst Mol & Cellular Biosci, Tokyo 1130032, Japan

来源：

NATURE REVIEWS GENETICS | 2001年 / 2卷 / 08期

关键词：

D O I：

10.1038/35084577

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The organization of cells and tissues is controlled by the action of 'form-giving' signalling molecules, or morphogens, which pattern a developmental field in a concentration-dependent manner. As the fate of each cell in the field depends on the level of the morphogen signal, the concentration gradient of the morphogen prefigures the pattern of development. In recent years, molecular genetic studies in Drosophila melanogaster have allowed tremendous progress in understanding how morphogen gradients are formed and maintained, and the mechanism by which receiving cells respond to the gradient.

引用

页码：620 / 630

页数：11

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