The histamine H4 receptor as a new therapeutic target for inflammation

被引：210

作者：

de Esch, IJP

Thurmond, RL

Jongejan, A

Leurs, R

机构：

[1] Vrije Univ Amsterdam, Leiden Amsterdam Ctr Drug Res, Dept Med Chem, NL-1081 HV Amsterdam, Netherlands

[2] Johnson & Johnson Pharmaceut Res & Dev LLC, San Diego, CA 92121 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2005年 / 26卷 / 09期

关键词：

D O I：

10.1016/j.tips.2005.07.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Following the sequencing of the human genome, data-mining efforts have revealed the existence of a new histamine receptor that is expressed at high levels in mast cells and leukocytes. The histamine H-4 receptor has a distinct pharmacological profile and the first compounds that act selectively on the H-4 receptor have been developed. Initial experiments in vivo with H-4 receptor antagonists indicate a role for the H-4 receptor in inflammatory conditions.

引用

页码：462 / 469

页数：8

共 59 条

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