Coexpression, coregulation, and cofunctionality of neighboring genes in eukaryotic genomes

被引：204

作者：

Michalak, Pawel ^{[1
]}

机构：

[1] Univ Texas Arlington, Dept Biol, Arlington, TX 76019 USA

来源：

GENOMICS | 2008年 / 91卷 / 03期

关键词：

gene expression; genome regulation; gene coexpression; gene clusters; eukaryotes;

D O I：

10.1016/j.ygeno.2007.11.002

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Accumulating evidence indicates that gene order in eukaryotic genomes is not completely random and that genes with similar expression levels tend to be clustered within the same genomic neighborhoods. The mechanism behind these gene coexpression clusters is as yet unclear. In this article, plausible biochemical, genetic, evolutionary, and technological determinants of this pattern are briefly reviewed. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：243 / 248

页数：6

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